It appears that no one was injured, which is good news.
1) See this report from TBD.com:
Fire crews fighting two-alarm house fire in Bloomingdale
January 17, 2011 - 04:01 PM
D.C. Fire and EMS fought a two-alarm fire in the Bloomingdale-LeDroit Park area in which several people sustained injuries. The bulk of the fire is out at this time.
The fire started in a two-story row house at 1923 Second Street NW and has reportedly spread to the building next door. Several streets in the area are blocked off for fire crews.
Twitter user 2lilwaynenprisn shot a brief video at the scene: http://yfrog.com/317iiz .
2) And Prince of Petworth has a post on the fire as well:
Horrible Fire in Bloomingdale/Ledroit Park Monday Afternoon
17 January 2011 10:04 PM